Job Description
Computational Biologist (Vaccine R&D)
On Site Pearl River NY
12+ month
$35-40/hour
POSITION SUMMARY
We are seeking a highly motivated contractor with a passion for using high-dimensional single cell immune profiling data in conjunction with innovative computational approaches and systems immunology knowledge to transforming vaccine research. Responsibilities will be developing analytical tools used for bulk RNAseq, single cell RNAseq, TCR sequencing, BCR sequencing, and host immune profiling. This role will integrate multi-omics data with preclinical/clinical data and provide scientific insights to immune responses elicited by vaccines or pathogens. This person will collaborate in a cross-functional teams and make strong impact to all stages of vaccine R&D.
Required Qualifications:
- Ph.D. in a relevant scientific field with a strong background in computational biology or bioinformatics.
- Extensive experience in analyzing multi-omics data (e.g., genetics, bulk RNA-seq, single-cell RNA-seq, spatial omics, proteomics, etc.) for biomedical research.
- Experience in biomarker discovery, particularly in the context of vaccine or immunology research.
- Familiarity with public omics databases and data repositories.
- Familiar with Linux environments, high-performance computing and/or cloud computing environment and broad experience with open-source bioinformatics tools to generate immunological insight.
- Strong communication and collaboration skills with the ability to work effectively in a hybrid team environment.
Preferred Qualifications:
- Extensive hand-on experience generating immunological insight from single cell sequencing data is highly desirable.
- Knowledge of machine learning techniques applied to biological data.
- Familiarity with artificial intelligence-empowered multimodal foundation models such as scGPT, UCE, scFoundation, Mal-ID
- Strong organizational skills and attention to detail in managing multiple projects and deadlines.
- Ability to document code thoroughly to ensure reproducibility and clarity for collaborative projects.
Hard Skills:
- Integrate and analyze multi-omics datasets (e.g., transcriptomics, proteomics, metabolomics) to identify biomarkers and molecular signatures relevant to vaccine efficacy and safety.
- Familiar with state-of-art technology related to bulk RNAseq, single cell RNAseq, TCR profiling, and BCR profiling.
- Leverage public omics databases (e.g., GEO, ENCODE, UK Biobank, CELL×GENE) to support hypothesis generation and validation. Provides scientific insights to innate and adaptive immune responses induced by vaccines.
Skill: 10X Single Cell, BCR TCR, Bioinformatics, Computational biology, data science, Next Generation Sequencing (NGS), transcriptomics, immunology, Vaccines, proteomics, and Genomics.
System One, and its subsidiaries including Joulé, ALTA IT Services, and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.
System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law. Ref: #568-Clinical
Job Tags
Contract work, For contractors, Local area,